Alveolar macrophages instruct CD8+ T cell expansion by antigen cross-presentation in lung. Cell Reports, 2022; 41 (11): 111828 DOI: 10.1016/j.celrep.2022.111828 ...

The immune cell repertoire is composed of many different cell types that are orchestrated in response to infection and other ...

The recent clinical trial in lymphoma using tumor antigen-loaded DCs (Hsu et al, Nature Med 1996; 2: 52) demonstrates the efficiency of the use of professional antigen presenting cells (APCs) for ...

In order to target the correct cells for killing, naive CD8 + T cells must be primed by contact with antigen-presenting cells (APCs), which mediate the uptake of virus-infected cells and present ...

Although not as effective as dendritic cells, these macrophages can also function as antigen-presenting cells. After activation, they begin to differentiate into histiocytes and epithelioid cells ...

Jennifer Connors, David Joyner, Nathan Mege, et al. Lipid nanoparticles (LNP) induce activation and maturation of antigen-presenting cells in young and aged individuals, 07 November 2022, PREPRINT ...

When a booster was given in the same location, those already-on-alert macrophages captured the antigen and activated the memory B cells more efficiently. In turn, this made high quality antibodies.

Researchers from Nara Institute of Science and Technology (NAIST) found that antigen-specific killer T cells (CD8+ T cells) rapidly expand in the lungs when primed by antigen-presenting lung ...