A decade ago, UB researchers shed some light on an enduring neuroscience mystery: How exactly does a mutated huntingtin protein (HTT) cause Huntington’s disease? They found that HTT is something like ...

Early research shows replacing brain immune cells slows a rare brain disease, with potential implications for treating ...

Kamal et al. investigated the role of APP in axonal transport by comparing the steady-state levels of kinesin-I (a microtubule motor protein) and putative kinesin-I cargoes in sciatic nerve axons, the ...

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a progressive neurological disease with an average age of onset of 43 years and an average life expectancy of only 3 ...

Takeaway Giant axonal neuropathy (GAN) is a progressive neurodegenerative disorder. It develops from a genetic mutation that causes your nerve cells to stop functioning.

Augustine Therapeutics Raises EUR 17 Million in a Series A First Closing to Advance Lead Candidate Into Clinical Development in Neurological Diseases Published Jun 26, 2024 1:00am EDT ...

They found that two specific signaling proteins, GSK3ß and ERK1, were expressed more in the neurons of Huntington’s disease patients, so they prevented them from functioning in the neurons of fruit ...

This inhibition of GSK-3ß actually led to less defects in the axonal transport process and less neuronal cell death, while inhibiting ERK1 led to more transport problems and more cell death.