Dr. Hazen says these results indicate that beta-2 adrenergic receptors can be regulated from a second PAG binding site that acts as a custom "dimmer switch" for the adrenaline signaling pathway.

Dr. Hazen says these results indicate that beta-2 adrenergic receptors can be regulated from a second PAG binding site that acts as a custom "dimmer switch" for the adrenaline signaling pathway.

"We believe the beta-2-adrenergic pathway should be more deeply investigated as a possible target to reduce the inflammatory symptoms related to COVID-19. The next step is to perform clinical trials ...

Beta-blockers, commonly used to treat heart disease, work by blocking the beta-adrenergic receptors in the heart, saving heart cells from cell death.

Can Beta-2-Adrenergic Pathway Be a New Target to Combat SARS-CoV-2 Hyperinflammatory Syndrome?-Lessons Learned From Cancer. Front Immunol. 2020 Sep 30;11:588724. doi: 10.3389/fimmu.2020.588724.

In fact, there was a 22% improvement in median overall survival in those taking beta blockers, compared with those who were not (23.7 vs 18.6 months; hazard ratio, 0.878; P = .02).

Both the beta-less mice and the control mice ate the same amounts, but because the beta-less group could not expend the extra calories, they grew very fat." ...

Although beta-adrenergic–receptor antagonists reduce morbidity and mortality in patients with mild-to-moderate chronic heart failure, their effect on survival in patients with more advanced ...

Beta-adrenergic signaling mechanisms are of central importance to cardiovascular health and disease. Modulation of these pathways represents an important pharmacologic approach to the treatment of ...

Dr. Hazen says these results indicate that beta-2 adrenergic receptors can be regulated from a second PAG binding site that acts as a custom "dimmer switch” for the adrenaline signaling pathway.

"Not All Beta-adrenergic Receptors Cause Heart Disease Along The Same Pathway." ScienceDaily. ScienceDaily, 23 April 2007. <www.sciencedaily.com / releases / 2007 / 04 / 070421213918.htm>.