Investigators led by Navdeep Chandel, Ph.D., the David W. Cugell, MD, Professor of Medicine in the Division of Pulmonary and ...

In fighting chronic infections or certain cancers, CD8+ T cells—the immune system's frontline soldiers—eventually become ...

It is important to understand whether alteration in nutrient utilization in CD8+ T cells alters the epigenetic, transcriptional, and functional states throughout differentiation.

The study, Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection, is published in the Journal of Experimental Medicine (DOI: 10.1084/jem.20241148).

To home in on what triggers the differentiation in these T cells, Joshi and his colleagues silenced 40 genes in CD8 T cells, one at a time. They then examined how the cells fared when faced with a ...

KLF2 prevents aberrant CD8 T cell differentiation in acute LCMV infection. Credit: Science (2025). DOI: 10.1126/science.adn2337 ...

• These stem cell-like memory CD8+ T cells are key for clearing infections, driving the elimination of cancerous cells, and can provide decades-long protection.

Researchers have discovered a way to make the immune system’s T cells significantly more effective at fighting cancer. By ...

CD8⁺ T cells are the immune system's frontline warriors, charged with detecting and eliminating cancer cells. But in the hostile and chronic environment of tumors, these cells often falter.

In cell culture assays, ApoE4 CD8+ T cells wriggled across a layer of brain endothelial cells more efficiently than did their E3 counterparts. In the brains of 6-month-old mice, Halters noticed that ...

In the thymus, precursor cells undergo a series of selection steps to differentiate into either CD4+ helper T cells or CD8+ cytotoxic T cells, with the outcome largely dictated by T cell receptor ...