The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...

Genetic inhibition of RyR1-mediated calcium-induced calcium release reveals its minimal role in skeletal muscle contraction and its critical contribution to malignant hyperthermia risk You are free to ...

MHH scientist investigates how pro-inflammatory cytokines interfere with muscle metabolism and actively transform muscles.

Cancer patients often lose excessive amounts of weight. This affects up to 80% of patients and is mainly due to a decrease in ...

New research has identified the specific biological mechanism behind the muscle dysfunction found in myotonic dystrophy type 1 (DM1) and further shows that calcium channel blockers can reverse these ...

Scientists discover that muscles repair themselves by moving thousands of internal nuclei, a rapid process that is key after ...