For this article, Steve Bunk interviewed Tak W. Mak, medical biophysics professor, Ontario Cancer Institute, University of Toronto. Data from the Web of Science (ISI, Philadelphia) show that Hot ...

Two apoptotic cell-death pathways exist in mammals — a cell-intrinsic pathway and a cell-extrinsic pathway — and these distinct pathways converge with the activation of the caspase cascade.

where it bound to a caspase-activating protein, Apaf-1. But "it was not clear which of the 12 human caspases were recruited by Apaf-1," Martin recalls. There was an exciting suspicion that they formed ...