Histones not only keep DNA organized, but also help regulate gene expression. How? Scientists are using ChIP and PCR to find out. To examine changes in histone modification during blood cell ...

So far, a number of histone variants have been found and localized to specific areas of chromatin. For instance, H2A.Z is a variant of H2A and is often enriched near relatively inactive gene ...

the basic structural units of chromatin composed of a histone core wrapped with DNA. At the time, researchers were unsure whether histones in the nucleosomes dissociated or remained bound to the DNA ...

"It has been overlooked that histone genes could be a rate-limiting ... The new technology -- Cleavage Under Targeted Accessible Chromatin (CUTAC) -- focuses on small, fragmented DNA non-coding ...

"It has been overlooked that histone genes could be a rate-limiting ... The new technology—Cleavage Under Targeted Accessible Chromatin (CUTAC)—focuses on small, fragmented DNA non-coding ...

A new review highlights the pivotal role of LSD1 (lysine-specific demethylase 1) in regulating critical cellular processes ...

This is particularly true for histone proteins, which are key components of chromatin and typically “live” for about 100 days before being replaced. Over time, proteins are subjected to ...

The fusion protein binds to the LacO domains (1), and incorporates the specialized centromeric histone CENP-A into and along neighboring chromatin (2). In turn, the region of CENP-A-containing ...

Approximately 50% of chromosomes and chromatin is protein. These include histones, transcription factors, nuclear receptors, co-activators, co-repressors, histone modifying enzymes, nucleosome binding ...