When they compared protein expression between neutrophils and their progenitors, one protein caught their attention: loop-extrusion loading factor nipped-B-like protein (NIPBL). This factor, which ...

within which the chromatin is folded into loops," Palmisano said. "These loops enable contact between 'genomic sites' that lie far apart in the linear genomic sequence. These contact points are ...

"This results from averaging of loops formed in separate cells. Dictyostelium does not possess these clusters, but it does have chromatin loops, which could be even more noticeable than in humans.

The researchers behind the new paper infected cultured human lung cells with SARS-CoV-2 and analyzed chromatin’s 3D architecture, the progressive folding into chromosomal compartments, domains, and ...