Investigating chromatin's 3D architecture reveals its influence on gene regulation, shedding light on mechanisms underlying ...

While it can be helpful for learners to begin with the linear presentation of how stretches of DNA form genes, this ...

The instructions to make a cell are encoded in DNA strands that are wrapped in proteins and RNA, and wound together into a 3D structure called chromatin.

“A single-cell atlas of in vivo mammalian chromatin accessibility external link, opens in a new tab.” Cell. Published online August 2, 2018. doi: 10.1016/j.cell.2018.06.052. Hannah A. Pliner et al., ...

Chromatin is the tightly-coiled structure of DNA and proteins which is used to store the genetic information inside the nucleus of a cell. The chromatin in a human cell contains around two metres ...

Every type of cell has a characteristic chromatin structure that includes closed chromatin, which is tightly wound around nucleosomes and is relatively inactive, and open chromatin, ...

These cell-specific gene expression patterns, which ensure that a brain cell is different from a skin cell, are partly determined by the three-dimensional (3D) structure of the genetic material ...

A cell's nucleus has to hold the entire genome. To do that, the DNA must be carefully arranged and compacted by proteins called histones into a complex known as chromatin. Now scientists have ...

More information: M. Andrés Blanco et al, Chromatin-state barriers enforce an irreversible mammalian cell fate decision, Cell Reports (2021).DOI: 10.1016/j.celrep.2021.109967 ...

Every cancer starts with a single cell, and Jackson Laboratory (JAX) researchers have found a precise and reliable way—whole-genome profiling of open chromatin—to identify the kind of cell ...