Ueda and his team selected 17 CRY1 mutations, and added each mutant CRY1 into different mouse embryonic stem cells that lacked all cryptochrome genes. When the mice grew up, they then analyzed ...

Laboratory studies by researchers at the Sidney Kimmel Cancer-Jefferson Health (SKCC) have found an unexpected role for the circadian clock gene CRY1, in prostate cancer progression. They say ...

CRY1 is well known for its role in regulating circadian rhythms. Abnormalities in the gene have been tied to sleep-related illnesses like delayed sleep phase disorder, but its role in cancer ...

Here, we report the essential role of the Arabidopsis CRY1 N-terminal domain (CNT1) in the light activation of CRY1 photoreceptor activity. Yeast two-hybrid assay, in vitro binding, in vivo chemical ...

This study established an efficient method for conducting gene-rescue experiments in mutant mice. Applying the method to knock in a series of CRY1 mutants into Cry1 -/-:Cry2 -/- mice, researchers ...

Researchers at Rockefeller University in New York have found that a variant in the gene CRY1 slows the internal clock that determines when you feel sleepy.

But in the mutation, CRY1 is active for longer periods, skewing the timing. The result is delayed sleep phase disorder, or DSPD, in which the 24-hour clock becomes delayed.

The circadian clock is entrained to the daily cycle of day and night by light signals at dawn and dusk. Plants make use of both the phytochrome (phy) and cryptochrome (cry) families of photoreceptors ...

Daughters were found to be more fussy than their parents. Mutation in CRY1 led to the development of DSPD, which affects up to 10 per cent of the population, according to clinical studies.

This study established an efficient method for conducting gene-rescue experiments in mutant mice. Applying the method to knock in a series of CRY1 mutants into Cry1 -/-:Cry2 -/- mice, researchers ...