A predictive biophysical model that integrates protein-DNA structures and sequences to accurately determine genomic binding sites and affinities of DNA-binding proteins.

A new study shows that over 99% of the human genome can be accurately assembled by focusing on 65 diverse humans.

Investigating chromatin's 3D architecture reveals its influence on gene regulation, shedding light on mechanisms underlying ...

Their findings, published in the Proceedings of the National Academy of Sciences, pave the way for solid-state, label-free DNA sequencing technologies with implications for precision medicine ...

Researchers at the University of Toronto have invented a new method that uses DNA sequencing to measure metabolites. This enables rapid and precise analysis of biological compounds, such as sugars ...

Thus, elevated sequencing errors at non-B DNA motifs should be considered in low-read-depth studies (single-cell, ancient DNA, and pooled-sample population sequencing) and when scoring rare variants.

In the late 2000s, IBM proposed the idea of DNA transistors, conceptualized with a dielectric metal sandwich structure and electrostatic traps to simultaneously allow ratchet-like control and sensing ...