Today, scientists know that the endomembrane system includes the endoplasmic reticulum (ER), Golgi apparatus, and lysosomes. Vesicles also allow the exchange of membrane components with a cell's ...

Multiple observations indicate the link between prostate carcinogenesis, stress of endoplasmic reticulum (ER stress), and impairment of Golgi morphology. We reported that PCa cells employ a ...

Notably, this increase was unaffected by blocking the conventional ER-to-Golgi trafficking protein pathway and the exosomal release pathway, thus confirming that PARK7 was released via an ...

"Researchers once thought that the Golgi apparatus was no more than an outgrowth of an organelle called the endoplasmic reticulum," said Graham Warren, professor of cell biology at Yale and a ...

Proteins usually undergo modifications during or after their synthesis in the endoplasmic reticulum (ER) and Golgi apparatus network inside eukaryotic cells. One such modification is glycosylation ...

Proteins usually undergo modifications during or after their synthesis in the endoplasmic reticulum (ER) and Golgi apparatus network inside eukaryotic cells. One such modification is glycosylation ...

First, the amount of Golgi apparatus could be used to select only the most effective T-cells for adoptive transfer. “Essentially, if you just use the Golgi apparatus as a simple marker, if T-cells ...

ATF6 release from the ER membrane is followed by cleavage within the Golgi apparatus. The activated form enhances the expression of ER chaperone-encoding genes and other genes required for the ...

Conclusions: Our findings provide proof-of-concept that targeting ER-Golgi homeostasis is therapeutically beneficial in lung cancer cell lines. No significant financial relationships to disclose. This ...