Specifically, PP2A-deficient CD8+ T cells exhibited: 1. Reduced production of key effector cytokines, including interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) 2.

A study published in Nature identifies a pathogenic subset of CD8+ memory T-cells that promote airway tissue inflammation and recurrent respiratory diseases through an effector molecule.

The healthy brain hosts very few T cells. However, they can be summoned to the brain when threats arise. This seems to be the case in people with AD or PD, whose CSF and brain tissue swarm with CD8+ T ...

About the study A CD8+ T cell atlas was created using data from 68 studies, 961 single-cell immune profiling samples, and over 1.1 million cells across 42 conditions.

In humanized mice, a single intravenous dose of 10 or 30 µg CD8-L829-tLNP-CD19 induced near-complete B cell depletion within three hours, with measurable CAR expression on CD8 + T cells ...

The researchers show that T cell exposure to interleukin-15 -- an immune factor important for Tcm formation -- and their expression of a protein named TCF1 engages the PPARβ/δ pathway. TCF1 is ...