The peripheral endoplasmic reticulum (ER) forms a continuous, dynamic network of tubules that plays an important role in protein transport and quality control, cellular signaling, and stress response.

DJ-1 is critical for the integrity and function of endoplasmic reticulum-mitochondria tethering. Yi Liu *, Sirui Jiang, Xiaopin Ma, Sandra L. Siedlak, Sandy Torres, Shengdi Chen, Xiongwei Zhu ... in ...

The endoplasmic reticulum (ER) of columella root cap cells has been postulated to play a role in gravity sensing. We have re-examined the ultrastructure of columella cells in tobacco (Nicotiana ...

Abstract Summary Pharmacological enhancement of endoplasmic reticulum (ER) proteostasis is an attractive strategy to mitigate pathology linked to etiologically-diverse protein misfolding diseases.

A team of scientists has answered a long-standing question in cell biology, uncovering how the cell’s main energy currency, ATP, is transported into the endoplasmic reticulum (ER). Disrupted ...

Our cells are crisscrossed by a system of membrane tubes and pockets called the endoplasmic reticulum (ER). ... To fulfill this function, ubiquitin changes the shape of part of the FAM134B protein.

We found that endoplasmic reticulum stress markers, activating transcription factor 6, inositol-requiring enzyme 1a, protein kinase RNA-like endoplasmic reticulum kinase, C/EBP homologous protein, and ...

Aging and related diseases are associated with alterations in oxidative status and low-grade inflammation, as well as a decreased endoplasmic reticulum (ER) unfolded protein response (UPR).

In healthy cells (left), calcium flows from the endoplasmic reticulum (purple) to the lysosomes (red circle in center). Early endosomes (EEA1+), recycling endosomes (VPS35+), and late ...

Single nucleotide polymorphisms (SNPs) in endoplasmic reticulum (ER) stress response genes to predict first-line treatment outcome in patients (pts) with metastatic colorectal cancer (mCRC): Data from ...