The endoplasmic reticulum (ER) is central to protein synthesis, folding and modification, ensuring that the proteome of a cell remains functional and balanced. When the ER is overwhelmed by an ...

A newly developed luciferase-based reporter can detect problems in protein translocation and disulfide bond formation in the endoplasmic reticulum (ER), as reported by researchers at Science Tokyo ...

Aging-related diseases, including cancer, cardiovascular disorders and type 2 diabetes, are associated with defects in ...

Protein synthesis involves multiple steps that scientists can target to get rid of unwanted proteins. Enodia focuses on one of the earlier steps. After proteins are created by a ribosome, the next ...

Researchers at the University of Michigan found that mitochondria also accumulate misfolded proteins, which kills β-cells.

Development of luciferase-based highly sensitive reporters that detect ER-associated protein biogenesis abnormalities. iScience, 2024; 27 (11): 111189 DOI: 10.1016/j.isci.2024.111189 ...

We found that endoplasmic reticulum stress markers, activating transcription factor 6, inositol-requiring enzyme 1a, protein kinase RNA-like endoplasmic reticulum kinase, C/EBP homologous protein, and ...

Journal reference: Estébanez, B., et al. (2022) Resistance Training Modulates Reticulum Endoplasmic Stress, Independent of Oxidative and Inflammatory Responses, in Elderly People.

Tsukuba, Japan—Researchers have been studying the transcription factor SREBP, a critical regulator of lipid biosynthesis. Precursor SREBP proteins, located in the endoplasmic reticulum (ER) of ...

Endoplasmic reticulum (ER) stress and its main regulator GRP78 (glucose-regulated protein 78 kDa) appear to be involved in the pathogenesis of pulmonary diseases, and GRP78 was found to be a biomarker ...

In a study published in Nature Metabolism, researchers at the University of Michigan found that mitochondria also accumulate misfolded proteins, which kills β-cells.