Researchers have found a way to rejuvenate the glycocalyx, the “sugar shield” that bolsters the blood-brain barrier. Exciting ...

Qian, X., et al. (2025). Transferrin promotes fatty acid oxidation and liver tumor growth through PHD2-mediated PPARα ...

Article Title H3K14la drives endothelial dysfunction in sepsis-induced ARDS by promoting SLC40A1/transferrin-mediated ferroptosis ...

The Terasaki Institute for Biomedical Innovation (TIBI) has developed a novel organ-on-a-chip device for measuring electrical resistance across endothelial barriers. This chip has carbon-based ...

Researchers from Brown’s Carney Institute will investigate how the blood-brain barrier is involved in transmitting ...

Iron Shuttle One transporter, in particular, caught scientists’ eyes: transferrin. This large protein—picture a four-leaf clover—captures iron in the blood and then attaches itself to the barrier.

We engineered an adeno-associated virus (AAV) capsid, BI-hTFR1, that binds human transferrin receptor (TfR1), a protein expressed on the blood-brain barrier (BBB).” ...

Denali’s transport vehicle platform is an engineered antibody that targets transferrin receptor 1, which normally shuttles iron—essential for brain function—across the barrier.

An AAV capsid reprogrammed to bind human transferrin receptor mediates brain-wide gene delivery. Science, 2024; DOI: 10.1126/science.adm8386 ...