Well-established, traditional Kumada cross-couplings involve preformed Grignard reagents in dry ethereal solvent that typically react, e.g., with aryl halides via Pd catalysis to afford products ...

Grignard reagents are an essential ingredient in a common method for creating carbon-carbon bonds, the building blocks of organic molecules. These reagents were discovered 120 years ago, but due ...

It also leads to a major reduction in hazardous waste. Additionally, it is more difficult for water or oxygen to affect the Grignard reagents when less organic solvent is used.