Transcreener dAMP Exonuclease Assay: Measure TREX1 Enzyme Activity with a Mix-and-Read FP Readout Figure 1. Schematic Overview of the Transcreener dAMP FP Assay.

Combination of antiviral drugs inhibits SARS-CoV-2 polymerase and exonuclease and demonstrates COVID-19 therapeutic potential in viral cell culture. Communications Biology, 2022; 5 (1) DOI: 10. ...

However, SARS-CoV-2 has two key enzymes that allow it to replicate: the polymerase which reproduces its RNA and a proofreading exonuclease that corrects errors in the replication process.

Novel antiviral drug combinations demonstrate Covid-19 therapeutic potential. By combining inhibitors of polymerases and exonucleases--enzymes that allow SARS-CoV-2 to reproduce--researchers ...

When an SSB appears, polymerase epsilon approaches the nick before retracing its steps thanks to its exonuclease, allowing fork reversal to take place. The nick is repaired as an SSB, and ...