Specifically, they examined the behavior of a key chemical building block of fibrin, known as γ-chain cross-links (gamma chain cross-links), and how it affected clot formation.

Holle L, Pantazis J, Turecek P, Wolberg A. Clot formation and fibrinolysis assays reveal functional differences among hemostatic agents in hemophilia A plasma. Res Pract Thromb Haemost . 2024;8(1 ...

Fibrin clot formation represents the culminating step in the coagulation cascade, wherein soluble fibrinogen is converted into insoluble fibrin, creating a structural network essential for ...

Essentially, the interaction of SARS-CoV-2 spike glycoprotein with fibrinogen and fibrin can give rise to abnormal blood clot formation, driving, in turn, inflammatory processes.

In blood-vessel-model and live pig tests, the milli-spinner was able to reduce the volume of clots by up to 95%, allowing for successful clot removal on approximately 90% of first attempts.

Fibrin’s pro-inflammatory role in a wide variety of diseases has been known for some time, Quigley said. In the 1980s, research efforts included thrombolytics—drugs that break down blood clots.

Stanford researchers develop milli-spinner thrombectomy technology that shrinks blood clots without breaking them, showing higher success rates for stroke treatment.

But clots that don't dissolve or that form abnormally are worrisome. Some of the reasons such formation may occur include stickier than normal platelets due to inhaling cigarette smoke, there ...

Study results. Given the higher frequency and severity of abnormal blood clots in COVID-19 patients compared to other respiratory infections, it was hypothesized that SARS-CoV-2 might directly ...

New research suggests that abnormalities in the process of blood clot formation may contribute to the pathogenesis of Alzheimer's disease. The study, published by Cell Press in the June 10 issue ...