Metabolic functions include (4) the replenishment of neuronal glutamate via the glutamate–glutamine cycle, and (5) the transport of glucose from the vasculature.

Major depressive disorder (MDD) is a leading cause of disability worldwide and unfortunately no treatment without side effects is available. Previous reports have found unbalanced glutamate-glutamine ...

New research shows that elevated glutamate-glutamine (Glx) levels in the anterior insular cortex (AIC) make people more ...

Identification and Characterization of IMD-0354 as a Glutamine Carrier Protein Inhibitor in Melanoma. Molecular Cancer Therapeutics, 2021; molcanther.0354.2020 DOI: 10.1158/1535-7163.MCT-20-0354 ...

A total of 1209 patients with severe burns (mean burn size, 33% of total body-surface area) underwent randomization, and 1200 were included in the analysis (596 patients in the glutamine group and ...