Upon reaching the Golgi, proteoglycans (PGs) compete with SURF4 to bind Shh and promote the dissociation of SURF4 and Shh. The released SURF4 returns to the ER through COPI vesicles.

Researchers of the Hong Kong University of Science and Technology (HKUST) recently uncovered novel molecular mechanisms that regulate delivery of a planar cell polarity protein, Frizzled-6, to the ...

Some proteins in the transporter vesicles could, for example, be antibodies. So, the Golgi apparatus would package them into secretory vesicles to be released outside of the cell to fight a pathogen.

Notably, this increase was unaffected by blocking the conventional ER-to-Golgi trafficking protein pathway and the exosomal release pathway, thus confirming that PARK7 was released via an ...

Complementing these insights, advanced imaging approaches have revealed the three-dimensional, interwoven tubular network that facilitates ER-to-Golgi protein delivery, thereby redefining our ...

Yolk proteins (vitellogenins, VITs) are crucial lipid-carrying molecules that supply nutrients from the mother to embryos in ...

Brefeldin A (BFA) causes a block in the secretory system of eukaryotic cells by inhibiting vesicle formation at the Golgi apparatus. Although this toxin has been used in many studies, its effects on ...

Working with cells grown in the lab, Johns Hopkins researchers have identified a biochemical pathway that allows a structure within cells, called the Golgi apparatus, to combat stress caused by ...

Signaling pathway involving the Golgi apparatus identified in cells with Huntington's disease Date: March 7, 2018 Source: Johns Hopkins Medicine Summary: Working with cells grown in the lab ...

The Plant Cell, Vol. 12, No. 11 (Nov., 2000), pp. 2201-2217 (17 pages) We describe a green fluorescent protein (GFP)-based assay for investigating membrane traffic on the secretory pathway in plants.

November 22, 2016 Researchers at the University of Texas MD Anderson Cancer Center report that the Golgi apparatus may play a role in how lung cancer metastasizes. Their study, “ Epithelial-to ...