Published: 10 November 1956 An Electron Microscopic Study of the Ground Substance of Connective Tissue A. M. ASADI, T. F. DOUGHERTY & GEORGE W. COCHRAN Nature 178, 1061–1062 (1956) Cite this article ...

The fibrous proteins and ground substance produced by fibroblasts are what constitute the extracellular matrix (ECM), which makes up the bulk of connective tissue. The ECM has many roles within ...