Clascoterone cream 1% caused mild, reversible hypothalamic-pituitary-adrenal axis suppression under maximum-use exposure in patients with acne vulgaris, according to a study.“The FDA looked at ...

Sleep and the stress response share the same pathway: the HPA axis. When something disrupts the HPA axis functions, it can disrupt your sleep cycles as well. Let’s look at how this can happen.

Abstract and Introduction Abstract. Adrenal steroidogenesis is under the control of the hypothalamic–pituitary–adrenal (HPA) axis. Furthermore, metabolic factors including insulin and obesity ...

The HPA axis in 103 patients (73.6%) recovered during 2 years' postsurgical follow-up. In 57 patients (55% of this subgroup), it recovered within 12 months.

Importantly for clinically relevant biology, this was associated with prolonged dysregulation of the neuro-hormone system that manages stress, called the hypothalamic-pituitary-adrenal, or HPA, axis.

The answer is complex, and one that scientists are still reaching for; we don’t yet fully understand the directionality of the relationship between sleep disorders, cortisol, and the HPA axis.

Chronic stress dysregulates the HPA axis, leading to excess levels of cortisol and other stress hormones in the body. Elevated stress hormone levels can disrupt almost all of the body’s functions.