Hydrogen sulfide (H 2 S)-based mitochondrial energy metabolism blockade is an attractive tumor therapeutic modality. However, it is limited owing to metabolic plasticity, which allows tumors to shift ...
In patients with ischemic heart disease, myocardial ischemia–reperfusion injury (IRI) can aggravate their condition even worse, and diabetes increases their risk of myocardial IRI. Pathological ...
Endothelial-to-Osteoblast Conversion (EC-to-OSB) regulates bone formation and homeostasis via the Kindlin-2/Piezo1/TGFβ/Runx2 axis. Reduced Kindlin-2 in endothelial ...
Combined experimental and theoretical tools that include biochemical and molecular biology approaches, genome, transcriptome, and proteome analyses, and comparative methods, have advanced our ...
Glycine, a non-essential amino acid derived from serine, plays an increasingly recognized role in metabolic regulation. Epidemiological studies ...
EPFL scientists have identified a molecular pathway that protects cells from lipid oxidation and ferroptosis, a regulated ...
A recent study published in the journal Frontiers in Endocrinology investigated the role of the short-chain dehydrogenase/reductase 42E member 1 (SDR42E1) enzyme in regulating sterol metabolism and ...
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