p53, the tumor suppressor found in roughly half of all human cancers, works by signaling cell death, thus keeping cell growth in check. But p53 can be deleted during transcription or mutated by ...

Although there are tumor suppressor genes in normal cells to prevent cancer, gene mutations can cause a normal cell to become ...

The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.