Investigations. Immunohistochemical analysis for DNA mismatch repair proteins, germline mutation analysis of MSH2. Diagnosis. Lynch syndrome with a heterozygous germline mutation in MSH2.

as it revealed I had a mutation in my MSH2 gene." Having Lynch syndrome means Cara's lifetime risk of developing another primary bowel cancer or other types remains high. She was diagnosed with ...

The MLH1, MSH2, MSH6 and PMS2 gene mutations can lead to colorectal cancer, gastric, ovarian, and endometrial cancers and are colloquially known as Lynch syndrome. Almost one in 300 people have ...