These cells then migrated to a nearby motor control region of the brain-the striatum-where they developed into cells known as medium spiny neurons, the major cells lost in Huntington's disease.

These cells then migrated to a nearby motor control region of the brain—the striatum—where they developed into cells known as medium spiny neurons, the major cells lost in Huntington’s disease.

More than 80% of activated medium spiny neurons in the nucleus accumbens expressed reelin mRNA, with average expression about 10 times greater compared to neurons that were not activated by cocaine.

These cells then migrated to a nearby motor control region of the brain—the striatum—where they developed into cells known as medium spiny neurons, the major cells lost in Huntington’s disease.

Newly generated striatal neurons rescue motor circuitry in a Huntington’s disease mouse model. Cell Reports, 2025 DOI: 10.1016/j.celrep.2025.115440 ...

The analysis revealed a crucial threshold: medium spiny neurons with up to 150 repeats maintained normal expression patterns, but those with more than 150 showed substantial changes — in some ...

Prior studies have demonstrated that cocaine's effects in the nucleus accumbens occur at medium spiny neurons, which are the principal neuronal type in this brain region and express receptors for ...