Adult human hearts possess limited regenerative abilities, so losing cardiomyocytes (CMs) after injury can result in contractile dysfunction and heart failure. In contrast, neonatal mammalian hearts ...

These properties led Lee and colleagues to investigate cadherin molecule functioning in synovial lining and in autoimmune arthritis. Initial investigations in healthy mice demonstrated that ...

First, other candidate molecules, including agrin, ephrinB1 and N-cadherin, did not induce vesicle aggregation, whereas neuroligins did. Further, chimeric proteins in which extracellular regions ...