Leishmaniasis is a parasitic disease that affects up to 1 million people worldwide each year. It is caused by the protozoan ...

To replicate, Leishmania needs lipids—essential molecules for many cellular functions. Contrary to previous beliefs, the amastigote form of the parasite, which multiplies in humans, does not produce ...

Leishmania: A Parasite That Hijacks Our Cells’ Resources to Multiply  A discovery by an INRS doctoral student sheds light on ...

"Once past the parasitophorous vacuole it can renovate the erythrocyte, obtain nutrients and avoid destruction by the body's immune system." ...

However, LDH becomes localized to the parasitophorous vacuole membrane (PVM) during the parasite intracellular development (LDH in red and nuclei in blue). The top panel show oocysts stained only ...

The host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole, Guillermo Arango Duque, Armando Jardim, Étienne Gagnon, Mitsunori Fukuda ...

These findings clarified that IFN-γ-dependent p62 has the unique role of gathering in the parasitophorous vacuole of toxoplasma through IFN-γ stimulation and activating the antigen-specific ...

While we know that parasite biomolecules make their way across the membrane, known as the parasitophorous vacuole until recently, it was unclear exactly how the molecules traversed these spaces.

Malaria is caused by a protozoan parasite that replicates within an intraerythrocytic parasitophorous vacuole. Release (egress) of malaria merozoites from the host erythrocyte is a highly ...

PAPERS TO WATCH I. Coppens et al.," Toxoplasma gondii sequesters lysosomes from mammalian hosts in the vacuolar space," Cell , 125:261-74, April 21, 2006. This outstanding paper shows that the ...

When RBCs are invaded by Plasmodium falciparum, a parasitophorous vacuole is formed around the parasite preventing exposure to the host cytosol. The parasitophorous vacuole membraneis produced ...