While much research focuses on oncogenic proteins and signaling pathways in aggressive cancers, fewer studies investigate how normal cells transform into ...

Even though the molecular mechanisms underlying colorectal adenoma carcinogenesis remain largely unknown, the Guangdong team was able to define a causative role for low GPT1. "We analyzed ...

This study is the first to reveal the dual regulatory role of copper metabolism imbalance and cuproptosis in the development of inflammatory bowel disease (IBD) and colorectal cancer (CRC ...

This study is the first to reveal the dual regulatory role of copper metabolism imbalance and cuproptosis in the development ...

Additionally, mutations in DNA damage response transducers, such as ATM and POLE, and mismatch repair pathway genes MSH2 and MSH6, were frequent and significantly associated with a high TMB.

Exploring the mutational landscape of colorectal cancer Researchers used mutational analysis to identify gene mutations that may drive carcinogenesis in colorectal tumors with high tumor mutation ...