Paxillin is a focal-adhesion associated protein implicated in the regulation of integrin signaling and organization of the actin cytoskeleton. Paxillin associates with numerous signaling molecules ...

Induced mechanical coupling of paxillin to β3 VE/YA integrin arrests the FA-sliding, thereby disclosing an essential structural function of paxillin for the maturation of β3 integrin/talin clusters.

Paxillin contains several protein–protein binding motifs for Src homology 2 (SH2) and SH3 domain–containing proteins, five leucine- and aspartate-rich (LD) domains, and four double–zinc ...

“Disrupting the interaction of paxillin with focal adhesions bears direct relevance in cancer treatment,” said Ravi Salgia, M.D., Ph.D., the Arthur & Rosalie Kaplan Chair in Medical Oncology at City ...

When paxillin and C-terminal targeting domain of FAK (FAT) interact at a specific docking site, they must shrink in size and stay that way to fit a restricted space.

Since paxillin is present in all cells as a link between integrins and the cytoskeleton, it also serves as a marker to visualize the dot-like and line-like anchoring points, i.e. focal adhesions.

Paxillin purified from chicken gizzard smooth muscle migrates as a diffuse band on SDS-PAGE gels with a molecular mass of 65-70 kD. It is a protein of multiple isoforms with pIs ranging from 6.31 to 6 ...

Abstract 517 Background: BC invasion is mediated by Src and its downstream target, the adhesion protein, paxillin (Pax). A randomized phase II trial of L + the Src inhibitor dasatinib demonstrated ...

To better understand paxillin’s role, the team turned to one of its main binding partners, known as focal adhesion kinase or FAK. The search has proved daunting. These two proteins share a large ...

Since paxillin is present in all cells as a link between integrins and the cytoskeleton, it also serves as a marker to visualize the dot-like and line-like anchoring points, i.e. focal adhesions.