Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1+ progenitor CD8 T cells to improve immunotherapy. Nature Immunology , 2024; DOI: 10.1038/s41590 ...

Among several hundreds of positive hits, they focused on one important enzyme, glucose-6-phosphate dehydrogenase (G6PD), which is a rate-limiting enzyme in the pentose-phosphate pathway ...

The abstract by Wu et al entitled, “Identification of Two Subtypes and Prognostic Characteristics of Lung Adenocarcinoma based on Pentose Phosphate Metabolic Pathway-related Long Non-Coding RNAs,” ...