These vectors were transformed into the Salmonella cells. The researchers fused the viral antigens to the SipB signal peptide (SipB160 protein), which effectively expresses the antigens on the cells.

Raman, V., et al. (2023) Intracellular Salmonella delivery of an exogenous immunization antigen refocuses CD8 T cells against cancer cells, eliminates pancreatic tumors and forms antitumor immunity.