During most eye infections or injuries, neutrophils, immune cells found in the blood, are usually the first line of defense.

The findings add a new dimension to the source of autoimmune disease by showing that a mechanism other than B-cell receptor signaling is responsible for removing self-reactive B cells, study co ...

During most eye infections or injuries, neutrophils, immune cells found in the blood, are usually the first line of defense.

The researchers discovered that depleting TLR9 impairs central tolerance and causes mice to produce increased numbers of self-reactive B cells and antibodies. Meffre and Barrat's teams found that ...

Summary: Unlike most tissues, the retina doesn’t summon neutrophils—the body’s typical first responders—when injured. Instead ...

“Our data challenge the current paradigm that BCR signaling alone is responsible for the deletion of self-reactive B cells in the bone marrow, since we demonstrate that TLR9 signaling plays an ...

The researchers discovered that depleting TLR9 impairs central tolerance and causes mice to produce increased numbers of self-reactive B cells and antibodies. Meffre and Barrat's teams found that ...

How regulatory T cells halt aberrant, self-reactive T cells Study reveals new therapeutic target to subdue autoimmune inflammation caused by loss of regulatory T cell function Date: January 24, 2023 ...

The researchers said they discovered that depleting TLR9 stops central tolerance from occurring. In mice, this resulted in decreased self-reactive B cells and antibodies.

To help stop this from happening, the immune system tries to eliminate self-reactive B cells by exposing them to self-antigens as they develop in the bone marrow. This process, known as central ...