Super-enhancers are the most active type of enhancer, and they can be identified by their unique molecular tags. Because super-enhancers can simultaneously and powerfully activate many genes, ...

More information: Inderpreet Sur et al, Shared requirement for MYC upstream super-enhancer region in tissue regeneration and cancer, Life Science Alliance (2025). DOI: 10.26508/lsa.202403090 ...

The researchers went on to demonstrate that deleting the super-enhancer or knocking out the hnRNPF gene in cell lines effectively slowed the growth of pancreatic cancer cells by more than 80%.