Therapeutic strategies aim to modulate complement pathways, microglial activity, and astrocyte functions to restore synaptic balance in neurodevelopmental and neurodegenerative disorders.

Researchers at Ruhr University Bochum, Germany, have studied the impact of two brain areas on the nature of memory content. The team from the Department of Neurophysiology showed in rats how the ...

CLAIM: Lack of sleep can cause the brain to “eat itself” FACT: Misleading. While sleep deprivation could lead to brain ...

Fragile X syndrome is the most common genetically-caused autism spectrum disorder. It causes a range of developmental issues, ...

The laboratory of Ege Kavalali, professor and chair of the Department of Pharmacology, published a paper in Nature ...

Within the neural circuitry electrical and chemical information is transferred at the synapse. Dysregulation of synapse formation or function has been linked to a variety of neurological diseases ...

Microglia, Pediatric Neurology, Autism Spectrum Disorder, Epilepsy, Neuroinflammation, Neurodevelopment Kaur, H. (2025) The Role of Microglia in Pediatric Neurological Disorders. Neuroscience and ...

The fragments also directly compromise synapses they encounter along the way, according to a preprint posted February 24 on bioRxiv. Specifically, tau fragments containing the microtubule binding ...

However, the intricate mechanisms governing these processes have remained elusive due to the presence of multiple functional domains within Munc13, each playing distinct roles in neurotransmitter ...