The laboratory of Ege Kavalali, professor and chair of the Department of Pharmacology, published a paper in Nature ...

First discovered as proteins found on synaptic vesicles and at the presynaptic plasma membrane, SNAREs are members of a family of highly conserved proteins that reside on vesicles (v-SNAREs ...

They did this at low and neutral pH values, such as those found in the so-called synaptic vesicle. After the toxin docks onto the receptor, this vesicle-like cell organelle takes up the toxin and ...

The study introduces new tools for measuring the intracellular calcium concentration close to transmitter release sites, which may be relevant for synaptic vesicle fusion and replenishment. This ...

However, the intricate mechanisms governing these processes have remained elusive due to the presence of multiple functional domains within Munc13, each playing distinct roles in neurotransmitter ...

Between impulses the transmitter molecules are rapidly removed from the synaptic cleft to prevent ... the presynaptic neuron and restored inside a vesicle ready to be used again.