Initiation of biological therapy within the first year of Crohn’s disease diagnosis was associated with a higher rate of transmural healing, as well as decreased risk for bowel damage ...

Early initiation of biologic therapy in patients with Crohn’s disease (CD) is associated with higher rates of transmural healing and leads to improved long-term outcomes. In CD, early initiation ...

Nearly 40% of newly diagnosed Crohn’s patients achieved transmural remission within 3 months — a higher proportion than seen in earlier studies, which mostly focused on long-standing or trial ...

Transmural healing was defined as PICMI≤10 and response as a change of >20 points with excellent discriminative validity (AUROC 0.96, 95% CI 0.93-0.99). Conclusion ...

Source Reference: Focht G, et al "Development, validation and evaluation of the Pediatric Inflammatory Crohn's Magnetic Resonance Enterography Index (PICMI) from the ImageKids study ...