Hospital for Sick Children in Toronto researchers are reporting that targeted RNA sequencing can detect clinically actionable ...

In primary CMN cell cultures, siNRAS Q61K inhibited the production of the variant transcript and reduced NRAS variant allele mRNA levels without affecting conventional melanocytic markers.

Mosquitoes engineered to swap out an amino acid in a key protein were resistant to malaria infection, preventing them from transmitting the disease.

“With an allele frequency between 8% and 12%, approximately 1.6 to 2.4 million men and 3.1 to 4.5 million women of NH-AFR ancestry carry this allele,” the team wrote.

DOI: 10.1016/j.jmoldx.2024.07.005 Mayo Clinic researchers found that a gene variant, the TPMT∗8 allele, is associated with reduced metabolism of the thiopurine class of drugs.

After conditioning on the presence of this allele, no other genetic variant reached genome-wide significance, underscoring the key role of HLA-DRB1*01:03 in severe ulcerative colitis.

New research suggests that having two copies of the gene variant APOE4 could be a cause of developing Alzheimer’s. The study also found that people with two copies of APOE4 were more likely to ...