Endotoxin refers to a component of the outer cell membrane of Gram-negative bacteria called lipopolysaccharide (LPS). LPS is the biologically active portion of naturally occurring endotoxin complexes.

As thoroughly covered in your recent article (C&EN, Oct. 28, 2024, page 26), the issue of replacing the traditional natural product test for endotoxin, limulus amoebocyte lysate (LAL), with a ...

Inadequate endotoxin testing places patients at risk. Knowing the relative strengths and weaknesses of available test methods is crucial to maintaining quality and safety. Endotoxins are small, ...

flashfilm/Getty Images . Bacterial endotoxin is another term used for lipopolysaccharides (LPS), complexes that are located in the outer cell membrane of Gram-negative bacteria and blue-green algae. 1 ...

In all cases, a protein purity level of >85% was obtained from one-step purification. Low endotoxin levels of 0.01 EU/µg were achieved without additional endotoxin removal steps (Figure 2). Figure 3.

Purpose It is well known that endotoxins in storage medium may stimulate cytokine production and expression of adhesion molecules as well as endothelial damage in human corneal grafts. It has been ...

Every human who has medical intervention has benefited from horseshoe crabs. That’s right. For decades, the fossil-looking, blue-blooded arthropod has played an integral role in endotoxin testing.

With the use of commercially prepared endotoxin derived from Escherichia coli 0111 (phenol-water extraction) it was found that 1 microgm. of endotoxin produced positive reactions in 5 of 6 rabbits ...

M. tuberculosis, which kills more than 1 million people a year, uses the ESX-4 type VII secretion system to transports its potent exotoxin. Six years ago, Michael Niederweis, Ph.D., described the ...

Exotoxin A is an extracellular enzyme that is produced by most clinical strains of Pseudomonas aeruginosa. It is a single-chain polypeptide (molecular weight, 71,000) with A and B fragments that ...