Synergistic effects between mTOR complex 1/2 and glycolysis inhibitors on non-small cell lung carcinoma metabolism. Authors: Suhua Jiang1, Zhengzhi Zou2, Peipei Nie2, Yuanyuan Zhuang2, Juan He2, and ...

Sin1, a mTOR component, is crucial for T lymphocyte maturation, cytokine production, and immune niche regulation. Downregulation of mTORC1 and mTORC2 signaling facilitates antibacterial immunity ...

While cancer metabolism in other organs is commonly associated with upregulated glycolysis and hyperactivation of PIK3/AKT/mTOR pathways, the unique bioenergetic demands of the central nervous ...

PAM (PIK3/AKT/mTOR) Signaling in glia during aging may contribute to glioma pathology. Astrocytes take up glucose, convert it to lactate (i.e. aerobic glycolysis) via lactate dehydrogenase (LDH ...

Furthermore, the signal activity of mTOR pathway and Pkm2 and Hk2 expression were reduced dramatically, while Tsc1 and Tsc2 expression were unaffected. Conclusions: The LOH status of KRAS G12D renders ...

In the past decade, there has been a growing amount of evidence suggesting mTOR's role in sarcoidosis. In 2017, researchers showed that activation of mTOR in macrophages could cause progressive ...