One of the major constituents of the cell-adhesion complex in epithelial cells is E-cadherin, a transmembrane protein involved in homotypic cell–cell adhesion. E-cadherin exerts a potent ...
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Antibody's outside-in signaling shows a route into cancer cellsMore information: Bin Xie et al, Outside-in engineering of cadherin endocytosis using a conformation strengthening antibody, Nature Communications (2025). DOI: 10.1038/s41467-025-56478-6 Provided ...
a novel antibody-drug conjugate (ADC) targeting cadherin-17 (CDH17). The data highlight SOT109's promising activity and tolerability profile across multiple disease models, reinforcing its ...
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