Apart from carrying the information to encode proteins in, RNA molecules can adopt intricate 2D and 3D structures. Specifically, the same RNA molecule can switch between ON and OFF structures, ...

The authors proposed two hypotheses: first, that methamphetamine induces neuroinflammation, and second, that it alters neuronal stem cell differentiation. These are valuable hypotheses, and the ...

This work establishes a versatile platform for expanding the genetic code in mammalian cells, paving the way for advanced protein engineering and functional studies in complex biological systems.

Researchers use generative AI to design synthetic enhancers that can effectively control gene expression in healthy mammalian cells.

Apurinic/Apyrimidinic Endodeoxyribonuclease 1 modulates RNA G-quadruplex folding of miR-92b and controls its expression in cancer cells ...

Traditionally, antibody expression is completed in mammalian cell expression systems, which is often both time-intensive and costly.

Mammalian cell lines are engineered by cell engineering strategies, such as anti-apoptotic engineering, metabolic engineering, cell cycle engineering, and protein PTM engineering, overexpression of ...

The constituent elements of an effective mammalian cell expression vector mainly include origin of replication, promoters, screening markers, enhancers, Poly A signals, antibiotic resistance genes, ...