Adult human hearts possess limited regenerative abilities, so losing cardiomyocytes (CMs) after injury can result in contractile dysfunction and heart failure. In contrast, neonatal mammalian hearts ...

Aadi Bioscience, Inc. , an oncology therapeutics company applying advanced technologies to established tumor biology to efficiently deliver advances in cancer treatment, today announced that the ...

Arif N, Zinnhardt M, Nyamay’Antu A, Teber D, Brückner R, Schäfer K, Li Y-T, Trappmann B, Grashoff C, Vestweber D. (2021) PECAM-1 supports diapedesis by tension-dependent dephosphorylation of ...

and patients with COPD (n=15) were collected to measure the mesenchymal markers α-smooth muscle actin, vimentin and collagen type I and the epithelial markers E-cadherin, ZO-1 and cytokeratin 5 and 18 ...

The journal Advanced Materials recently published a study introducing a new method for monitoring molecular processes deep ...

targeting cadherin-17 (CDH17). The data highlight SOT109's promising activity and tolerability profile across multiple disease models, reinforcing its potential to become a best-in-class ...

The intrinsic factor of cell senescence, PCBP2, was identified by unlabeled quantitative proteomics, and its biological role in in vitro replication senescence of human bone marrow mesenchymal stromal ...

Segmentation of the vertebrate body is first established during embryogenesis by the periodic formation of pairs of somites — for example, every 120 minutes in mouse, 90 minutes in chicken and ...

Translational research in the cardiovascular field is hampered by the unavailability of cardiac models that can recapitulate organ-level physiology of the myocardium. Outside the body, cardiac tissue ...

The treatment and prognosis of advanced colorectal cancer (CRC) remain a challenging clinical research focus. Here, we describe a new CRC tumor suppressor and potential therapeutic target: thymocyte ...

Subgroup analysis suggests that ECFC from patients with COPD on inhaled corticosteroids (ICS) (n=14; eight on ICS) exhibited significantly reduced senescence (Senescence-associated-beta galactosidase ...