Apart from carrying the information to encode proteins in, RNA molecules can adopt intricate 2D and 3D structures. Specifically, the same RNA molecule can switch between ON and OFF structures, ...

Liquid biopsies have transformed cancer testing. These tests detect signs of cancer using a simple blood draw instead of ...

This background noise uses up crucial reagents during small RNA sequencing and impacts the genome-mapped reads and miRNA mapping.

Limitations of this study include technical issues associated with single-cell RNA sequencing, limited sensitivity to detect extremely rare cell types, and a markedly heterogeneous cell population ...

As researchers continue to unravel the complexities of small RNAs, their potential applications in therapeutic strategies and agricultural improvements become increasingly evident. CD Genomics' small ...

Cancer Biology Subtypes and proliferation patterns of small intestine neuroendocrine tumors revealed by single cell RNA sequencing Einav Someach Debdatta Halder Avishay Spitzer Chaya Barbolin Michael ...

Here we profiled ten low-grade small intestine NET (SiNET) tumor samples as well as one mixed lung tumor by single-cell or single-nuclei RNA-seq. We find that SiNETs are largely separated into two ...

Autoimmune liver diseases (ALDs), including autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC), are complex conditions involving the liver's immune ...

Scientists have used emerging sequencing technology to map the expression of different forms of genes in human tissues. Research on RNA diversity in human tissues, led by scientists from the New ...

RNA sequencing (RNA-seq) is the gold standard for the discovery of small non-coding RNAs. Following a long-standing approach, reads shorter than 16 nucleotides (nt) are removed from the small RNA ...

Yale researchers are the first to analyze gene regulation patterns in tissue after developing novel spatial epigenetics mapping technology.