Mayo Clinic researchers identify a measurable genetic mutation as a significant predictor of metastasis and survival in pancreatic cancer
A new study by Mayo Clinic Comprehensive Cancer Center researchers found that the presence of a specific genetic mutation — KRAS circulating tumor DNA (ctDNA) — strongly indicates a higher risk of ...
eLife5d
Pu.1/Spi1 dosage controls the turnover and maintenance of microglia in zebrafish and mammals
Microglia are brain-resident macrophages playing pivotal roles in CNS development and homeostasis. Yet, the cellular and molecular basis governing microglia maintenance ...
bjo.bmj5d
Quantifying corneal endothelial cell death
A significantly higher rate of cell death was observed with the TUNEL assay, which labels nuclei with fragmented DNA, compared to the trypan blue exclusion method, which detects cells with disrupted ...
gut.bmj5d
Alcohol dysregulates miR-148a in hepatocytes through FoxO1, facilitating pyroptosis via TXNIP overexpression
Immunoblottings, luciferase reporter assays, chromatin immunoprecipitation and immunofluorescence ... the molecular regulation may assist in the development of good diagnostic markers, along with ...