Current treatment options for Gram-negative bacterial infections are limited, and recent studies of new antibiotic agents do not demonstrate the required efficacy to meet clinical needs.

Gram-negative bacteria show pink or red on staining and have thin walls. They release different toxins and affect the body in different ways. Gram-positive and Gram-negative are types of bacteria.

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By analyzing E. coli protein levels, scientists found a surplus of membrane shuttle proteins that may play a role in antibiotic resistance.

A team led by Paul Hergenrother at the University of Illinois Urbana-Champaign has discovered a new antibiotic that exclusively targets gram-negative bacteria and avoids wiping out the ecosystem ...

Gram stain revealed no bacteria. Blood cultures were then performed. Empirical treatment was started intravenously with ceftriaxone and vancomycin. By the next day he was afebrile and feeling better.

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The Infectious Diseases Society of America (IDSA) 2024 guidance on the treatment of AMR gram-negative infections has been published.

Compared with other methods, urine Gram stain moderately predicted gram-negative bacteria but added little value to UTI diagnosis in the ED, raising questions about its clinical utility.