[2] Good evidence exists for the use of anti-EGF receptor (EGFR) monoclonal antibody treatment as part of first-line combination chemotherapy including infusional 5-fluorouracil and for third-line ...

International Holding Company (IHC) has reported significant growth in its full-year 2024 financial results, underscoring its ability to drive strong performance and strategic portfolio management.

An EGFR gene mutation is one of the biomarkers a doctor often tests for after confirming a diagnosis of non-small cell lung cancer (NSCLC). Biomarkers can help guide treatment. EGFR mutations ...

The Islamabad High Court (IHC) has declared Section 7 of the Finance Act 2015 void ab initio, declaring it contradictory to the Constitution, and struck it down along with all orders and actions ...

Department of Respiratory and Critical Care Medicine, National Health Commission (NHC) Key Laboratory of Respiratory Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science ...

[84] Emerging data suggest that patients with NSCLC and EGFR exon 19 deletion have a longer survival following treatment with gefitinib or erlotinib compared with those with the L858R In a ...

This manuscript presents solid evidence suggesting that the loss of ZNRF3 and RNF43, two E3 ubiquitin ligases, leads to dysregulation of EGFR signaling in cancer. The authors propose that EGFR is a ...

Here we show that deleting the focal adhesion protein Kindlin-2 expression in hepatocytes using the Alb-Cre transgenic mice causes a severe inflammation, resulting in premature death. Kindlin-2 loss ...

Conventional immunohistochemistry (IHC) has long been regarded as the “gold standard” for the diagnosis of tissue pathology. However, the diagnostic-prognostic value of this technique is limited by ...

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