This month's cover highlights the article Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling by Joseph, Misha Kalarikkal and colleagues. The image shows a human ...

This led the authors to examine an alternative target of OMA1, the inner membrane protein OPA1, which is a key regulator of mitochondrial fusion. The elongated, branched networks of mitochondria ...

Advancing age causes reduced hippocampal neurogenesis, associated with age-related cognitive decline. The spatial relationship of age-induced alterations in neural stem cells (NSCs) and surrounding ...

The 0.25% PBS/gelatin/Triton solution applied in our protocol is used to permeabilize the tissue and increase the immunostaining efficiency. It has been found that rinsing the sections in such Triton ...

Using an in vitro reconstitution system, we describe a mechanism for how mitochondrial inner-membrane fusion is regulated by the ratio of two forms of Opa1. We found that the long-form of Opa1 (l-Opa1 ...