CRISPR Clinical Trials: A 2024 Update
Mar 13, 2024 · It is a remarkable time for the development of CRISPR -based therapies. In late 2023, we saw the first-ever approval of CRISPR-based medicine: Casgevy, a cure for sickle cell disease (SCD) and transfusion-dependent beta thalassemia (TDT).
CRISPR Clinical Trials: A 2023 Update
Mar 17, 2023 · CRISPR Therapeutics is testing two kinds of allogeneic CRISPR-modified CAR-T cells in phase 1 clinical trials. One targets CD70, a protein often present on the surface of cancerous cells in some lymphomas and some solid tumors.
More than 200 people have been treated with experimental CRISPR ...
Mar 10, 2023 · In the decade since scientists found they could use CRISPR to edit cell genomes, multiple clinical trials have sprung up to test the technology’s use for serious diseases.
The first human trial of CRISPR-based cell therapy clears safety ...
Aug 25, 2020 · In a study recently published in Nature Medicine, Lu et al. examined the feasibility and safety of using CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)-engineered,...
CRISPR Clinical Trials: A 2022 Update
Mar 29, 2022 · In our annual deep dive into CRISPR clinical trials, we guide you through the current landscape of clinical trials, outcomes, what we hope to learn from each trial, and what is coming next in the world of therapeutic genome editing.
How CRISPR Is Changing Cancer Research and Treatment
Jul 27, 2020 · CRISPR is a fairly new and highly precise gene editing tool that is changing cancer research and treatment. Researchers are using CRISPR to study how cancer grows and to find new potential treatments. CRISPR-based therapies are also being tested in …
An Update on the Application of CRISPR Technology in Clinical …
In this review, we first describe the function and applications of the CRISPR–Cas9 system. We next delineate how this technology could be utilized for gene therapy of various human disorders, including cancer and infectious diseases and highlight the promising examples in the field.
Five Years of Progress in CRISPR Clinical Trials (2019–2024)
Oct 18, 2024 · In this brief Perspective, we collate the latest information on therapeutic clinical trials featuring CRISPR, base and prime editing, across a range of both in vivo and ex vivo gene and cell therapies. Over the past five years, we have witnessed the launch of an exciting new era of genomic medicines based on recently developed CRISPR effectors.
CRISPR/Cas9 System as a Promising Therapy in Thalassemia and
Jan 10, 2025 · Clustered, regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein (Cas) system is a new gene editing tool that represents a revolution in gene therapy. This study aimed to review the clinical trials conducted to evaluate the efficacy and safety of the CRISPR/Cas9 system in treating thalassemia and sickle cell disease (SCD). We searched relevant literature using ...
CRISPR/Cas9 therapeutics: progress and prospects
Jan 16, 2023 · Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) gene-editing technology is the ideal tool of the future for treating diseases by...